Shell Oil Rig Runs Aground in Alaska





An enormous Shell Oil offshore drilling rig ran aground on an island in the Gulf of Alaska on Monday night after it broke free from tow ships in rough seas, officials said.




The rig, the Kulluk, which was used for test drilling in the Arctic last summer, is carrying about 139,000 gallons of diesel fuel and 12,000 gallons of lubricating oil and hydraulic fluid, the officials said.


A Coast Guard helicopter flew over the rig after the grounding at 8:48 p.m. and “detected no visible sheen,” said Darci Sinclair, a spokeswoman for a unified command of officials from Shell, Alaskan state agencies and other groups that has been directing the response since the troubles with the rig began last Thursday.


Ms. Sinclair said that more overflights were planned after daybreak on Tuesday, and that the unified command would be monitoring the fuel situation as it planned further actions. “The focus will be around salvage,” she said.


The 266-foot diameter rig ran aground on the east coast of Sitkalidak Island, an uninhabited island that is separated by the Sitkalidak Strait from the far larger Kodiak Island to the west. The nearest town, Old Harbor, is across the strait on Kodiak Island; it has a population of about 200 people.


Ms. Sinclair said the coast where the Kulluk ran aground has a combination of rocky and sandy terrain.


Earlier Monday, a Shell spokesman had said that the rig had been brought under control after towlines were reconnected to two ships during a break in what had been several days of extremely rough seas and high winds.


But late Monday afternoon the line from one of the ships, the Aiviq, became separated. Then several hours later, the other ship, the Alert, was ordered to disconnect its towline, out of concern for the safety of the ship’s nine-person crew. At the time, Ms. Sinclair said, swells were as high as 35 feet and winds were gusting up to 65 miles an hour.


The Kulluk, one of two rigs that Shell used to drill test wells off the North Slope of Alaska as part of the company’s ambitious and expensive effort to open Arctic waters to oil production, was being towed by the Aiviq to a Seattle shipyard for off-season maintenance when the towline initially separated during a storm on Thursday.


The Aiviq then lost power, and other support ships and a Coast Guard cutter were brought in to help with engine repairs and to reconnect towlines to the Kulluk, which does not have its own propulsion system. The 18 workers aboard the rig were evacuated by Coast Guard helicopters on Saturday.


Over the weekend, support crews struggled in 25-foot swells to reconnect towlines, succeeding several times. But each time the lines separated again, leaving the rig in danger of drifting toward land.


The Kulluk, which was built in Japan in 1983 and upgraded over the past six years at a cost of $292 million, is designed for icy conditions in the Arctic. It can drill in up to 400 feet of water and up to 20,000 feet deep. During drilling season it carries a crew of about 140 people, Mr. Smith said.


Shell has spent six years and more than $4 billion in its effort to drill in Arctic waters, one of the last untapped oil-producing regions in the United States. But the effort has faced regulatory hurdles and opposition from American Indian and environmental groups.


Last summer, the Kulluk drilled a shallow test well in the Beaufort Sea while another rig drilled a similar hole in the Chukchi Sea to the west.


But Shell announced in September that it would be forced to delay further drilling until this year after a specialized piece of equipment designed to contain oil from a spill was damaged in a testing accident.


The episode was one of a number of setbacks for the Arctic drilling program last year.


Shell now says it hopes to drill five exploratory wells in the region during the 2013 drilling season, which begins in mid-July.


Read More..

12 Foreign Stories From 2012 Worth Revisiting


Tyler Hicks/The New York Times







There were hundreds of memorable foreign stories from Times correspondents in 2012. Here is a sampling of 12 from across the world in reverse chronological order




1. For Congo Children, Food Today Means None Tomorrow


KINSHASA, Democratic Republic of Congo — Today, the big children will eat, Cynthia, 15, and Guellor, 13. Tomorrow, it will be the turn of the little ones, Bénédicte, Josiane and Manassé, 3, 6, and 9.


2. Dublin Journal: Not Worth the Paper It’s Built On


DUBLIN — As an emblem of the modern Irish condition, Frank Buckley is almost too apt. Dead broke, he lives in a house made of money.


3. American Children, Now Struggling to Adjust to Life in Mexico



Shaul Schwarz for The New York Times



IZÚCAR DE MATAMOROS, Mexico — Jeffrey Isidoro sat near the door of his fifth-grade classroom here in central Mexico, staring outside through designer glasses that, like his Nike sneakers and Nike backpack, signaled a life lived almost entirely in the United States. His parents are at home in Mexico. Jeffrey is lost.


4. Egypt’s Everywoman Finds Her Place Is in the Presidential Palace


CAIRO — Naglaa Ali Mahmoud wears an Islamic head covering that drapes down to her knees, did not attend college and never took her husband’s last name, because that is a Western convention that few Egyptians follow. She also refuses the title of first lady, in favor of simply Um Ahmed, a traditional nickname that identifies her as the mother of Ahmed, her eldest son.


5. A Superstar Televangelist in Pakistan Divides, Then Repents



Diego Ibarra Sanchez for The New York Times



KARACHI, Pakistan — THE audience erupted as Aamir Liaquat Hussain, Pakistan’s premier televangelist, darted around the television studio, firing off questions about Islam. “How many gates are there to heaven?” he challenged.


6. Elephants Dying in Epic Frenzy as Ivory Fuels Wars and Profits


GARAMBA NATIONAL PARK, Democratic Republic of Congo — In 30 years of fighting poachers, Paul Onyango had never seen anything like this. Twenty-two dead elephants, including several very young ones, clumped together on the open savanna, many killed by a single bullet to the top of the head.


7. Young Lives, Lost in the Fog of War


KABUL, Afghanistan — These days, Abdul Farhad tries to sleep with the lights on in his bedroom and his eyes wide open, because as soon as he closes them he is back in his shop in central Kabul and it is 11:30 a.m. on the eighth of September.


8. Corruption Is Seen as a Drain on Italy’s South



Gianni Cipriano for The New York Times



REGGIO CALABRIA, Italy — Italy’s A3 highway, begun in the 1960s and still not finished, starts outside Naples in the ancient hill town of Salerno and ends, rather unceremoniously, 300 miles farther south as a local street in downtown Reggio Calabria.


9. Reporting a Fearful Rift Between Afghans and Americans


SISAY OUTPOST, Afghanistan — How far is Kabul from the war? These days, if you drive south or west, no more than an hour and a half. You can go and be back for dinner — if you aren’t kidnapped or blown up.


10. Billions in Hidden Riches for Family of Chinese Leader


BEIJINGThe mother of China’s prime minister was a schoolteacher in northern China. His father was ordered to tend pigs in one of Mao’s political campaigns. And during childhood, “my family was extremely poor,” the prime minister, Wen Jiabao, said in a speech.


11. Long Retired, Ex-Leader of China Asserts Sway Over Top Posts


BEIJING — In a year of scandals and corruption charges at the commanding heights of the Communist Party, a retired party chief some had written off as a spent force has thrust himself back into China’s most important political decisions and emerged as a dominant figure shaping the future leadership.


12. Horrific Fire Revealed a Gap in Safety for Global Brands



ASHULIA, Bangladesh — The fire alarm shattered the monotony of the Tazreen Fashions factory. Hundreds of seamstresses looked up from their machines, startled. On the third floor, Shima Akhter Pakhi had been stitching hoods onto fleece jackets. Now she ran to a staircase.


Read More..

Redskins win NFC East, Broncos get top seed in AFC


RG3 and the Washington Redskins are heading to the playoffs as NFC East champions.


By winning their seventh straight game, the Redskins rolled to their first division title in 13 years with a 28-18 victory over the Dallas Cowboys on Sunday night. Next up for Robert Griffin III & Co.: a home playoff matchup next Sunday with the Seahawks — the third straight postseason game for Washington against Seattle.


"It's just a mindset change," the rookie quarterback said. "When you have all these guys coming to work every day, putting it on the line, we knew we couldn't afford to lose one game, we made sure we didn't"


Thanks to Houston's late-season slump, Denver and New England will have byes when the AFC playoffs begin next week.


The Texans fell from first to third in the conference Sunday when they lost 28-16 at Indianapolis, which welcomed back coach Chuck Pagano after nearly three months of treatments for leukemia.


AFC West champion Denver won its 11th straight game, 38-3 over Kansas City to secure the top seed. New England blanked Miami 28-0 for the second spot.


Minnesota edged Green Bay 37-34 to grab the final NFC wild card, sinking the Packers to the third seed. Those teams will meet again next Saturday night at Lambeau Field.


The other NFC matchup will have Seattle (11-5), which beat St. Louis 20-13, at Washington on Sunday at 4:30 p.m. ET.


Cincinnati (10-6) will be at Houston on Saturday at 4:30 p.m. ET, and Indianapolis (11-5) goes to at Baltimore (10-6) on Sunday at 1 p.m. in the AFC wild-card rounds.


The divisional round games will be hosted by Denver on Saturday, Jan. 12, followed by San Francisco (11-4-1) at night. On Sunday, Jan. 13, Atlanta (13-3) will host the early game, followed by New England (12-4).


Peyton Manning threw for three touchdowns as Denver (13-3) routed the Chiefs. New England got the second seed despite having the same record as Houston because it beat the Texans, who lost three of their final four games.


Adrian Peterson had 199 yards against the Packers, finishing with 2,097 — Dickerson's single-season rushing mark in 2,105. But it was rookie kicker Blair Walsh who won it with a 29-yard field goal as time expired.


"Ultimately we got the 'W,'" Peterson said. "I told myself to come into this game focused on one thing, and that's winning."


Green Bay would have been seeded second in the NFC by beating Minnesota.


"The road got a little tougher having to play on opening weekend, but we've got a home game and that's why you win the division," Aaron Rodgers said. "We get to go back home, and the game will be different. They won't have home-crowd advantage, and hopefully that will make a difference."


Baltimore Pro Bowl safety Ed Reed is looking forward to a reunion with Pagano. He wishes it would come a little later in the postseason.


"Chuck's like a dad to me," Reed said "He means a lot to me. I would have much rather seen them in the AFC championship game than the first game."


But Reed will see him next week at Baltimore.


The Ravens had a chance to move up to the AFC's third seed with a win and a New England loss. But Baltimore lost at Cincinnati as both teams played backups for much of the game.


Pagano coached the Ravens' secondary for three seasons and was promoted to coordinator last year. Players and coaches in Baltimore have kept in touch, offering encouragement as he fought through the cancer treatments.


"Going back to Baltimore, obviously there's some familiarity there," Pagano said. "We had four great years there as a family. It's a top-notch organization, you know, really good football club. It's a great challenge and they have a great team and they have great players all over the place."


The Colts were 2-14 last season and chose quarterback Andrew Luck with the top selection in the draft. Luck and offensive coordinator Bruce Arians, who stepped in as interim coach with Pagano sidelined, led the turnaround.


Next week, Pagano goes up against former boss John Harbaugh.


"I love his family, and he's one of my closest personal friends in coaching," Harbaugh said. "What he's been through is phenomenal, but we're all competitors so that gets set aside."


Houston beat Cincinnati in the opening round of last year's playoffs.


"I think it will be good," said Bengals QB Andy Dalton, who grew up in suburban Houston. "We played there last year and know the atmosphere and what it's going to be like. The experience last year will definitely help us."


The defending Super Bowl champion Giants are out of contention. When Chicago beat Detroit 26-24, the Giants (9-7) were eliminated, even though they routed Philadelphia 42-7.


"It hurts," said Eli Manning. "Each year you want to make the playoffs to give yourself an opportunity to win a championship; 9-7 last year was good enough. It wasn't good enough this year and we knew it wouldn't be."


Minnesota's win eliminated Chicago.


___


Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL


Read More..

F.D.A. Approves Sirturo, a New Tuberculosis Drug





The Food and Drug Administration announced on Monday that it had approved a new treatment for multidrug-resistant tuberculosis that can be used as an alternative when other drugs fail.




The drug, to be called Sirturo, was discovered by scientists at Janssen, the pharmaceuticals unit of Johnson & Johnson, and is the first in a new class of drugs that aims to treat the drug-resistant strain of the disease.


Tuberculosis is a highly infectious disease that is transmitted through the air and usually affects the lungs but can also affect other parts of the body, including the brain and kidneys. It is considered one of the world’s most serious public health threats. Although rare in the United States, multidrug-resistant tuberculosis is a growing problem elsewhere in the world, especially in poorer countries. About 12 million people worldwide had tuberculosis in 2011, according to Johnson & Johnson, and about 630,000 had multidrug-resistant TB.


A study in September in The Lancet found that almost 44 percent of patients with tuberculosis in countries like Russia, Peru and Thailand showed resistance to at least one second-line drug, or a medicine used after another drug had already failed.


Treating drug-resistant tuberculosis can take years and can cost 200 times as much as treating the ordinary form of the disease


“This is quite a milestone in the story of therapy for TB,” Dr. Paul Stoffels, the chief scientific officer at Johnson & Johnson, said in an interview. He said the approval was the first time in 40 years that the agency had approved a drug that attacked tuberculosis in a different way from the current treatments on the market. Sirturo works by inhibiting an enzyme needed by the tuberculosis bacteria to replicate and spread throughout the body.


Sirturo, also known as bedaquiline, would be used on top of the standard treatment, which is a combination of several drugs. Patients with drug-resistant tuberculosis often must be treated for 18 to 24 months.


Even as it announced the approval, however, the F.D.A. also issued some words of caution.


“Multidrug-resistant tuberculosis poses a serious health threat throughout the world, and Sirturo provides much-needed treatment for patients who have don’t have other therapeutic options available,” Edward Cox, director of the office of antimicrobial products in the F.D.A.’s center for drug evaluation and research, said in a statement. “However, because the drug also carries some significant risks, doctors should make sure they use it appropriately and only in patients who don’t have other treatment options.”


The consumer advocacy group Public Citizen opposed approval in a letter to the F.D.A. in mid-December, saying that the results of a limited clinical trial showed that patients using bedaquiline were five times as likely to die than those on the standard drug regimen to treat the disease.


“Given that bedaquiline belongs to an entirely new class of drugs, it is entirely feasible that death in some cases was due to some unmeasured toxicity of the drug,” the letter said.


Sirturo carries a so-called black box warning for patients and health care professionals that the drug can affect the heart’s electrical activity, which could lead to an abnormal and potentially fatal heart rhythm. The warning also notes deaths in patients treated with Sirturo. Nine patients who received Sirturo died compared with two patients who received a placebo. Five of the deaths in the Sirturo group and all of the deaths in the placebo arm seemed to be related to tuberculosis, but no consistent reason for the deaths in the remaining Sirturo-treated patients could be identified.


Doctors Without Borders and the Bill and Melinda Gates Foundation, both active in the fight against tuberculosis and other global diseases, applauded the F.D.A.’s decision.


Jan Gheuens, interim director of the TB Program for the Gates Foundation, called it a “long-awaited event” and said the fight against TB had not benefited from new drugs in the way H.I.V. had. Beyond the benefits of the drug itself, he said the quick approval process could be a model for other drugs sorely needed in the developing world.


He also suggested, however, that more trials should be conducted to get a better understanding of the side effects that led to the black box warning.


The F.D.A. approved bedaquiline under an accelerated program that allows the agency to conditionally approve drugs that are viewed as filling unmet medical needs with less than the usual evidence that they work. The drug’s approval was based on studies that showed it killed bacteria more quickly than a control group taking the standard regimen, but it did not measure whether in the end patients actually fared better on bedaquiline. Johnson & Johnson will conduct larger clinical trials to investigate whether the drug performs as predicted.


In a statement responding to Public Citizen’s letter, a spokeswoman for Johnson & Johnson said the company was committed to supporting appropriate use of Sirturo and would “work to ensure Sirturo is used only where treatment alternatives are not available.”


Dr. Stoffels said the hope was that other new tuberculosis drugs would also be approved that, when used in combination with bedaquiline, could shorten and simplify the current standard of treatment. “That is still a long time away,” he acknowledged, but “this is a first step in a new regimen for TB.”


Read More..

Big in 2012, but the Future Is Hazy for Bonds


The big story in the markets this year was not about stocks.


Americans sold off their stock mutual funds, the most popular way to invest in American companies, at the fastest clip since 2008, the year the financial crisis began. That occurred despite the fact that the stock market itself rose steadily; the benchmark Standard & Poor’s 500-stock index ended the year up 13.4 percent.


Investors have been opting instead for the assumed safety of bonds. Money has been steadily flowing into mutual funds holding bonds of all sorts for the last four years, but the pace accelerated this year. The percentage of household investments in bonds shot up to 26 percent from 14 percent just five years ago, according to Morningstar.


Entering the new year, a growing number of professional investors are betting that the craze for bonds has gone too far, perhaps dangerously so, as has been evident in the headlines from the year-end reports from large investment firms. “Bond PAIN in 2013?” Wells Capital Management’s chief strategist asked. “Caution: Turn Ahead,” BlackRock analysts wrote. “The inflection year,” said Bank of America.


This is not the first time that analysts have forecast an end to the decades-long rally in bond values. But previously many of the voices predicting it were pessimists who believed that investors would sell off their bonds when they lost faith in the American government’s ability to pay back its bonds, forcing the government and many other bond issuers to pay higher interest rates. When interest rates rise, older bonds with lower interest rates are worth less.


While those previous forecasts have proved expensively wrong, this year the forecasters are being joined by many economic optimists who argue that a strengthening American economy is likely to make investors willing to embrace the risks involved in stocks, luring them out of bonds. The question, they say, is only how quickly it will happen.


“Mathematically, it’s next to impossible to get the kind of returns on bonds you’ve seen over the last few years,” said Kate Moore, the chief global equity strategist at Bank of America.


When the turn does ultimately come, it is likely to cause pain for at least some of the people who have been investing in bonds in recent years.


“You don’t want to be the last one out the door when the trends turn,” said Rebecca H. Patterson, the chief investment strategist at Bessemer Trust. “All good things come to an end and we want to make sure we’re in front of it.”


Most of the talk of investors shifting money from bonds into stocks relies first on the assumption that politicians in Washington are able to resolve the current impasse over the so-called fiscal cliff, the automatic spending cuts and tax increases that will go into effect if Congress and President Obama cannot come to an agreement, and the coming debate over the nation’s debt ceiling. If the political discord continues, it could renew investor attraction to the safety of bonds and put off any shift into stocks.


But a number of surveys suggest that professional investors are already starting to prepare for a change. Hedge funds polled by Bank of America said that they had more of their portfolio allocated to stocks than at any time since 2006.


All but one of the 13 bank strategists tracked by Birinyi Associates expects stock markets to rise in 2013. When 2012 began, the same strategists were predicting a downturn in share prices. Even among mutual fund investors, there are signs that the flows out of stocks and into bonds have been slowing down recently.


The preference for bonds has already been costly for retail investors. Over the last year, most types of American bonds have returned less than an investment in the S.&. P. 500. When inflation is factored in, the benchmark 10-year Treasury security is delivering negative returns.


But many investors are still rattled by the 2008 financial crisis and the turbulence in the stock markets since then, which have led to wild swings. Over the last five years, all major types of American bonds have done better than leading stock indexes.


The Federal Reserve has been engaged in an aggressive effort to buy bonds and drive down interest rates. The long term goal of that program is to encourage banks to lend money and to drive investors out of bonds. But in the meantime, falling interest rates have made bonds more attractive. The Fed has said it wants to keep rates low until 2015, though it could let them rise sooner if the economy picks up faster than expected. The 10-year Treasury hovered near 4 percent in recent years but has stayed below 2 percent for much of 2012.


Read More..

IHT Rendezvous: Republicans Consider Changing Electoral Vote Counting to Improve Presidential Odds

WASHINGTON — Not too long ago, political analysts assumed the Republicans had a clear advantage in the Electoral College, the system according to which each state, based on population, is given electors that in almost all cases are awarded on a winner-take-all basis, determining who will be the president of the United States. Today, it’s the Democrats who have the edge.

Page Two

Posts written by the IHT’s Page Two columnists.

Start by looking at the past seven presidential elections, three won by Republicans, four by Democrats. Then put most states that went for one party in five of these seven elections into the red column for Republican, blue for Democrat and purple or toss-up for the others.

Three are caveats: North Carolina and Virginia voted Republican until recently; the trends, however, are so pronounced that they are more purple than red. Conversely, West Virginia voted Democratic in three of these contests, but has moved safely into the red ranks.

BLUE: The District of Columbia and 20 states, mainly on the coasts and in the progressive upper Midwest, with 256 electoral votes, are the Democrats’ base.

RED: 23 states, with 188 electoral votes, including much of the South, the Plains and Rocky Mountains states, are reliably Republican.

There are seven purple states — Florida, Ohio, North Carolina, Virginia, Colorado, Nevada and New Hampshire — with 94 electoral votes.

The upshot: In any normal election cycle, the Republicans have to win Florida and Ohio and at least three of the other five. Or they have to turn around some blue states, such as Pennsylvania and Iowa.

In the my latest Left From Washington, I write about how some Republicans
in states where Republicans control the state government are considering changing how those states assign their electoral votes, instead of the winner-take-all system used in most states, they would emulate Maine and Nebraska, where some of the state’s electoral votes are awarded based on which presidential candidate carried a district.

As I write:

They see a possible test case in Pennsylvania, where Mr. Obama won the popular vote by more than five percentage points, rolling up huge margins in Philadelphia and its suburbs and in Pittsburgh. Mr. Romney, however, carried 13 of the 18 congressional districts. If this new system were in effect, the Republicans would have gotten 13 of the state’s 20 electoral votes while getting trounced in the popular vote. If this occurred in mainly Republican states, it would erase the Democrats’ Electoral College advantage.

Politics do shift. In 1988, the Republicans won California, Michigan, Pennsylvania, New Mexico, Connecticut, Maryland and Vermont; all now are considered safely part of the blue base.

Read More..

Purported photo of new BlackBerry phone with QWERTY keyboard leaks









Title Post: Purported photo of new BlackBerry phone with QWERTY keyboard leaks
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Adrian Peterson tops 2,000 yards


MINNEAPOLIS (AP) — Adrian Peterson's remarkable comeback season now has a magic number to punctuate it.


Peterson became the seventh player to rush for 2,000 yards in a season, plowing through the Green Bay Packers for a 20-yard gain that put him over the top in the third quarter Sunday.


Peterson entered the game needing 102 yards to join O.J. Simpson, Eric Dickerson, Barry Sanders, Terrell Davis, Jamal Lewis and Chris Johnson in the 2,000-yard club. Peterson is the only one to do it after reconstructive knee surgery.


Dickerson's single-season record of 2,105 yards set in 1984 isn't far out of reach, either. Peterson needed 208 yards when the day began, and was 64 yard away as the fourth quarter approached.


The Vikings punted a few plays after Peterson's big run, and the crowd gave him a standing ovation when the achievement was announced. Peterson took it all in stride, waving politely, but otherwise not making anything special out of it in a game the Vikings needed to win to make the playoffs. He simply didn't have time to reflect on the long, arduous path it took for him to get there after tearing the ACL in his left knee.


It was only last December when Peterson crumpled to the turf in Washington, two ligaments torn, leaving many to wonder if his career would ever be the same.


Well, it hasn't been.


Peterson vowed from the very beginning to return better than ever from an injury that has ended the careers of so many before him. There weren't many believers, including in his own locker room.


But a combination of uncommon genetics, unshakable determination and a smart rehabilitation plan from Vikings athletic trainer Eric Sugarman had Peterson back in the starting lineup on opening day.


Peterson scored two touchdowns in the opener, but didn't top 100 yards in a game until Week 4 when he went for 102 against the Lions. As the season went on, the scar tissue in his knee started to break up and Peterson took off like a purple rocket.


His cuts are sharper, his vision better, his patience is making the difference between a 4-yard plunge through the line and a 40-yard dash down the sideline.


He went on a breathtaking eight-game run, amassing 1,313 yards and topping 200 yards twice in four games to vault into the MVP discussion and make 2,000 yards a possibility.


When asked this week to describe his running style in one word, Peterson replied: "Vicious."


That certainly sums it up.


He got off to a fast start with 61 yards and a touchdown on the first two drives, hearing chants of "MVP! MVP!" just before he surged into the end zone for a 7-yard score and a 10-0 Vikings lead. He also had runs of 12 and 21 yards early to get the Vikings going in this win-and-they're-in game.


The Vikings have followed Peterson's lead, needing a victory over the Packers on Sunday to get into the playoffs in what most observers expected to be a rebuilding year. Peterson has carried the offense on his broad shoulders, turning the Vikings into a throwback attack that relies almost exclusively on the run for its big plays.


With second-year quarterback Christian Ponder going through some highs and lows, and the Vikings missing top receiver Percy Harvin with an ankle injury, the passing offense has ranked last in the league. Peterson is averaging more yards per rush than Ponder does per pass and his seven rushes of 50 yards tied him with Sanders in 1997 for the NFL record.


All the while, Peterson has said he'd take the first postseason berth in three years over 2,000 yards any day. But it was no secret that the individual achievement was important to him.


Unlike baseball, the NFL has few numbers that immediately grab the public's attention. One of those is 2,000 yards, especially in this new pass-happy league. Peterson entered the game with 1,898 yards, more than 400 better than Seattle's Marshawn Lynch, who was in second place.


"I definitely want to keep the running backs highlighted," Peterson said this week. "It's started to turn into more of a spread, quarterback-friendly NFL. But just keep letting them know that there are going to be running backs that can do this."


___


Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL


Read More..

Questcor Finds Profit for Acthar Drug, at $28,000 a Vial


Kevin Moloney for The New York Times


Christina Culver with her son Tyler, 6, at home in Colorado Springs this month. In 2007, Tyler was hospitalized when the price of Acthar soared.





THE doctor was dumbfounded: a drug that used to cost $50 was now selling for $28,000 for a 5-milliliter vial.


The physician, Dr. Ladislas Lazaro IV, remembered occasionally prescribing this anti-inflammatory, named H.P. Acthar Gel, for gout back in the early 1990s. Then the drug seemed to fade from view. Dr. Lazaro had all but forgotten about it, until a sales representative from a company called Questcor Pharmaceuticals appeared at his office and suggested that he try it for various rheumatologic conditions.


“I’ve never seen anything like this,” Dr. Lazaro, a rheumatologist in Lafayette, La., says of the price increase.


How the price of this drug rose so far, so fast is a story for these troubled times in American health care — a tale of aggressive marketing, questionable medicine and, not least, out-of-control costs. At the center of it is Questcor, which turned the once-obscure Acthar into a hugely profitable wonder drug and itself into one of Wall Street’s highest fliers.


At least until recently, that is. Now some doctors, insurance companies and investors are beginning to have doubts about whether the drug is really any better than much cheaper alternatives. Short-sellers have written scathing criticisms of the company, questioning its marketing tactics and predicting that its shareholders are highly vulnerable.


 That Acthar is even a potential blockbuster is a remarkable turn of events, considering that the drug was developed in the 1950s by a division of Armour & Company, the meatpacking company that once ruled the Union Stock Yards of Chicago. As in the 1950s, Acthar is still extracted from the pituitary glands of slaughtered pigs — essentially a byproduct of the meatpacking industry.


The most important use of Acthar has been to treat infantile spasms, also known as West syndrome, a rare, sometimes fatal epileptic disorder that generally strikes before the age of 1.


For several years, Questcor, which is based in Anaheim, lost money on Acthar because the drug’s market was so small. In 2007, it raised the price overnight, to more than $23,000 a vial, from $1,650, bringing the cost of a typical course of treatment for infantile spasms to above $100,000. It said it needed the high price to keep the drug on the market.


“We have this drug at a very high price right now because, really, our principal market is infantile spasms,” Don M. Bailey, Questcor’s chief executive, told analysts in 2009. “And we only have about 800 patients a year. It’s a very, very small — tiny — market.”


Companies often charge stratospheric prices for drugs for rare diseases — known as orphan drugs — and Acthar’s price is not as high as some. Society generally tolerates those costs to encourage drug companies to develop crucial, possibly lifesaving drugs for these often neglected diseases.


But Questcor did almost no research or development to bring Acthar to market, merely buying the rights to the drug from its previous owner for $100,000 in 2001. And while the manufacturing of Acthar is complex, it accounts for only about 1 cent of every dollar that Questcor charges for the drug.


Moreover, the tiny “orphan” market soon became much bigger. Before long, Questcor began marketing the drug for multiple sclerosis, nephrotic syndrome and rheumatologic conditions, even though there is little evidence that Acthar is more effective for those other conditions than alternatives that are far cheaper. And the company did so without being required to prove that the drug actually works. That is because Acthar was approved for use in 1952, before the Food and Drug Administration required clinical trials to show a drug is effective for a particular disease. Acthar is essentially grandfathered in.


Today, only about 10 percent of the drug’s sales are for infantile spasms. The new uses, Mr. Bailey has told analysts, represent multibillion-dollar opportunities for Acthar and Questcor, its sole maker.


The results have been beyond even the company’s wildest dreams. Sales of Acthar, which accounts for essentially all of Questcor’s sales, totaled nearly $350 million in the first nine months this year, up 145 percent from the period a year earlier. In the same period, Questcor’s earnings per share nearly tripled, to $2.12. In the five years after the big Acthar price increase in August 2007, Questcor shares rose from around 60 cents to about $50, in one of the best performances of any stock in any industry.


But in September, the shares plummeted after Aetna, the big insurer, said it would no longer pay for Acthar, except to treat infantile spasms, because of lack of evidence the drug worked for other diseases. The stock now trades at $26.93.


Peter Wickersham, senior vice president for cost of care at Prime Therapeutics, a pharmacy benefits manager that has found the drug is possibly being overused, says the huge increase in Acthar’s price for patients “just invites the type of scrutiny that it’s received.”


Read More..

IHT Rendezvous: The Rope, the App and Van Gogh in Amsterdam

AMSTERDAM—Consolation for disappointed art lovers who arrive in this city and realize that the Van Gogh Museum is closed for renovation: Follow the red braided rope.

It’s affixed to the corner of the old museum building, leading away from the construction site and stretches to Museumplein, Amsterdam’s great museum square.

The red rope is part of Amsterdam’s most public Van Gogh installation, the Van Gogh Mile. In place until the Van Gogh Museum reopens in spring 2013, it connects the Van Gogh museum with the site of the temporary Van Gogh exhibition, the Hermitage museum, 2.2 kilometers across the historic center of Amsterdam.  The rope is the most visible part of a multidisciplinary art walk designed by Henk Schut for the Van Gogh Museum. The walk guides would-be visitors through Van Gogh’s life, thoughts and travels, while directing them to his famous paintings.

“By following the rope, you can let go and you can trust us,” said Mr. Schut, whose installation is inspired by the 900 letters Vincent Van Gogh wrote to his brother, Theo.

A Van Gogh Mile app can be downloaded from a free WiFi spot close to the start of the tour and is supported by iPhones, iPads and Android-based phones.

The first digital installment of the tour is activated at the head of the fountain basin on the Museum Square, just in front of the “IamAmsterdam” sign.  A tap on the device and the same place appears on the screen. As if looking through a camera, the monuments and buildings of the Museumplein move as the user moves the device. A sweep of the device downward shows the scene as an expanse of sunflowers in bloom.

“There are moments of poetic license to synthesize, to be inspired by his letters,” said Mr. Schut.

The augmented reality software transposes the courtyard of an old sanitarium in the south of France where Van Gogh spent some time into the inner courtyard of the Hermitage museum.

At a stop along the route in front of the Rijkmuseum, the user flies (with the help of their digital device and some imagination) through an open window to see a Rembrandt painting. An audio clip of a reading of one of the artist’s letters describing his reaction to Rembrandt’s art comes through the headphones.

The audio for the tour is all from Van Gogh’s letters, and is in either English or Dutch. Rather than explain the visual experiences, the snippets provide atmosphere.

David Kat, who co-created the app, describes Van Gogh’s letters used in the tour as “handwritten, sketch-like, quick thoughts.”

A third component of the tour ensures that not only smart-phone users benefit from the Van Gogh Mile. Loudspeakers hanging from trees, posts and house-fronts along the rope’s route broadcast more of Van Gogh’s letters. Other public installations, such as a picture frame bearing one of Van Gogh’s musings about art near the Amstel Church, are strewn along the path to be discovered by those who take their time in looking around.  By having walkers looking upward at a rope instead of downward at a map, Mr. Schut hopes to make the audience discover Amsterdam the way Van Gogh himself would have on his many solitary walks.

“It is a connection between looking and walking,” said Mr. Schut.

The detour from the Van Gogh Museum to the Van Gogh art at the Hermitage Museum, with its fragmented audio, fantastical images and physical installations is designed to inspire engagement with the artist, not provide biographical information on his life, explained Mr. Schut.

There are already plenty of sources for that.

Read More..